Authors: Andrew T. Krasley, William P. Malachowski, Hannah M. Terz, and Sabrina Tran Tien
Source: Organic Letters, Vol 20, March 21, 2018
Abstract: A new enantioselective desymmetrizing Mizoroki鈥揌eck reaction is reported. The process affords high yields and enantioselectivities of tricyclic structures containing all-carbon quaternary stereocenters. The substrates for the reaction are efficiently synthesized from Birch reduction鈥揳lkylation of benzoic acid and benzoate esters.